The Human GI Tract: A Vitamin-Producing Powerhouse

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Individuals complement B nutritional vitamins for quite a lot of causes: to stop vitamin B12 deficiency, stop delivery defects (B9 or folate), encourage hair progress (B7 or biotin), cut back blood ranges of homocysteine (B6, B9, B12, generally B2), amongst different results. And there’s no query that addition of B nutritional vitamins can certainly obtain particular well being advantages. Supplementation of vitamin B9 (folate, folic acid) by pregnant females, as an illustration, reduces the incidence of spina bifida in newborns, whereas supplementation of nicotinamide (a type of vitamin B3) reduces the incidence of basal and squamous cell pores and skin carcinomas, and supplementation of B7 or biotin restores hair progress for some individuals.

However it’s turning into clearer and clearer that microbes within the human intestinal microbiome have the potential for manufacturing of considerable portions of B nutritional vitamins that embody B1, B2, B3, B5, B6, B7, B9, and B12. Akkermansia and plenty of species of Bacteroidetes, as an illustration, are vigorous producers of a number of B nutritional vitamins. Yogurts fermented with Streptococcus thermophilus produce substantial portions of folate (although much more can be produced if extended fermentation was used, not the meager 4 hour fermentation utilized by industrial yogurt producers), as can Bifidobacterium longum and a few strains of L. reuteri.

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Right here’s my query: If intestinal microbes are capable of produce the total panel of B nutritional vitamins, are the obvious advantages of B vitamin supplementation actually simply compensating for a disrupted microbiome that lacks B vitamin-producing species? Chubby and overweight individuals, as an illustration, lack Akkermansia and species of Bacteroidetes and have over-proliferation of Firmicutes, tipping the stability in the direction of much less B vitamin manufacturing. Does restoration of a wholesome intestinal microbiome present adequate B nutritional vitamins that makes supplementation pointless?

Whereas the proof stays preliminary, I do consider that we’re heading in that route. In different phrases, the human physique and microbiome have tailored to producing their very own vitamins and the obvious want for exogenous vitamins is a contemporary phenomenon, a product of the microbiome that we have now disrupted resulting from antibiotics, glyphosate, herbicides and pesticides in meals, weight problems, abdomen acid-suppressing medication and the myriad different components that disrupt the microbes residing in our GI tracts.

It implies that many well being questions should be reconsidered in mild of the contribution of the intestinal microbiome. You possibly can start to understand, for instance, that issues over excessive homocysteine ranges which have been blamed on lack of nutritional vitamins B6, folate, B12 and generally B2 (riboflavin) might have been misplaced, as these vitamins are all bacterial merchandise. In different phrases, whereas larger ranges of homocysteine, particularly ranges of 14 micromol/L or better have been confidently related to elevated danger for cardiovascular loss of life, despair, dementia, and varied cancers, eight randomized placebo-controlled scientific trials have demonstrated that B vitamin supplementation that reduces blood ranges of homocysteine don’t cut back danger. In different phrases, there’s a disconnect between blood ranges of homocysteine and danger for these circumstances, and supplementing B nutritional vitamins has no influence on the incidence of illness.

What if larger homocysteine ranges are as an alternative seen because the failure of the intestinal microbiome to provide B nutritional vitamins? Supplementing B nutritional vitamins would then, in fact, don’t have any impact on illness incidence as a result of a disrupted intestinal microbiome and its accompanying endotoxemia can be the reason for elevated cardiovascular danger, despair, dementia, and most cancers. Trillions of microbes, residing and dying each hour of day by day, launch their breakdown merchandise into the bloodstream (“endotoxemia”) that inflames arteries, causes atherosclerotic plaque rupture, raises blood stress, triggers despair, prompts irritation in varied organs together with the mind, causes or worsens insulin resistance. The answer would due to this fact not be supplementation of B nutritional vitamins, however to handle the disrupted intestinal microbiome that entails a shift away from species that produce B nutritional vitamins. Taking B nutritional vitamins with out addressing the disrupted microbiome chargeable for decreased B vitamin ranges then achieves nothing. It additionally means that larger blood ranges of homocysteine can function markers for dysbiosis and small intestinal bacterial overgrowth, SIBO, and doesn’t counsel a necessity for B vitamin supplementation.

Are you starting to understand that insights into the intestinal microbiome ought to trigger us to rethink ALL frequent continual illnesses that afflict fashionable individuals? “Deal with” despair with SSRI antidepressant medication whereas ignoring the dysbiosis/SIBO and endotoxemia and you’ve got solely managed to Band-Help among the emotional turmoil of despair however leaves you inclined to creating fibromyalgia, irritable bowel syndrome, ulcerative colitis, kind 2 diabetes, weight problems, hypertension, atrial fibrillation, diverticular illness, and so forth. “Treating” psoriatic arthritis with a biologic, prednisone, and naproxen that block inflammatory pathways whereas ignoring dysbiosis/SIBO and endotoxemia likewise leaves you inclined to a protracted checklist of continual illnesses.

It implies that each physician ought to be an professional within the microbiome and easy methods to assess it, enable you to handle and reconstruct it, simply as they need to all be specialists in vitamin and well being.  However that’s not the case, since speak of vitamin and the microbiome doesn’t yield revenues like performing a colonoscopy, carotid endarterectomy. or injections for macular degeneration do. That’s why efforts to reconstruct a wholesome intestinal microbiome are as much as YOU. That is why I wrote my new guide, Tremendous Intestine: A 4-Week Plan to Reprogram Your Microbiome, Restore Well being and Lose Weight  that gives readers with a step-by-step path to not simply “deal with” well being circumstances, however tackle the precise trigger.



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