Early Menopause Could Increase a Girl’s Odds for Dementia

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TUESDAY, March 1, 2022 (HealthDay Information) — Ladies who enter menopause early could also be extra prone to develop dementia later in life, new analysis signifies.

Throughout menopause, manufacturing of the feminine intercourse hormone estrogen drops dramatically and a lady’s durations come to an finish. Whereas girls usually enter menopause of their early 50s, many achieve this earlier — both naturally or on account of a medical situation or remedy comparable to a hysterectomy (removing of the uterus).

This massive research discovered that girls within the U.Ok. who entered menopause earlier than age 40 have been 35% extra prone to develop dementia later in life than girls who began menopause round age 50.

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What’s extra, girls who entered menopause earlier than age 45 have been 1.3 instances extra prone to develop dementia earlier than their sixty fifth birthday, the brand new research confirmed.

“Ladies with early menopause may have a detailed monitoring of their cognitive decline in scientific apply,” mentioned research writer Dr. Wenting Hao, a Ph.D. candidate at Shandong College in Jinan, China.

The upper threat for dementia could also be because of the sharp estrogen drop that takes place throughout menopause, Hao mentioned.

“Estrogen can activate mobile antioxidants comparable to glutathione, scale back ApoE4, the most typical genetic threat issue within the pathogenesis of dementia, and scale back amyloid plaque deposition within the mind,” she defined.

The build-up of amyloid plaques within the mind is without doubt one of the hallmarks of Alzheimer’s illness, the most typical kind of dementia.

This doesn’t imply that girls who begin menopause early are powerless in opposition to dementia, Hao mentioned.

“Dementia will be prevented, and there are a variety of the way girls who expertise early menopause could possibly scale back their threat of dementia,” he mentioned. This consists of getting common train, collaborating in leisure and academic actions, not smoking or utilizing alcohol, and sustaining a wholesome weight, she mentioned.

For the research, researchers in contrast age at menopause and dementia analysis amongst 153,291 girls (common age: 60) who have been a part of the UK Biobank, a big database of genetic and well being data on individuals dwelling in the UK. They appeared for every type of dementia, together with Alzheimer’s.

Postmenopausal girls are at larger threat of stroke than pre-menopausal girls, and stroke could trigger vascular dementia, however the research discovered no hyperlink between age at menopause and the chance of the sort of dementia.

Whereas girls who entered menopause early have been at increased threat of dementia, those that entered menopause at age 52 or later had comparable charges of dementia as girls who began menopause at age 50 or 51, the research confirmed.

The brand new findings held after researchers accounted for different elements that will increase dementia threat, together with age ultimately examination, race, schooling, cigarette and alcohol use, physique fats, coronary heart illness, diabetes, earnings and leisure and bodily actions. The research didn’t embrace data on whether or not girls had a household historical past of dementia or if girls entered menopause early for pure or medical causes, which might have an effect on the findings.

The findings have been introduced Tuesday at a gathering of the American Coronary heart Affiliation held in Chicago and on-line. Analysis introduced at medical conferences is often thought of preliminary till printed in a peer-reviewed journal.

These findings are in line with different research displaying a larger threat of dementia amongst girls with untimely or early menopause, mentioned Dr. Stephanie Faubion, medical director of the North American Menopause Society and director of the Mayo Clinic Heart for Ladies’s Well being.

“The early lack of estrogen is linked with an elevated threat of a number of antagonistic long-term well being outcomes, and dementia is only one of them,” mentioned Faubion. Others embrace coronary heart illness, brittle bone illness, osteoporosis, temper issues, sexual dysfunction and early dying.

There could also be a job for hormone substitute remedy, she mentioned.

“Along with suggesting monitoring of those girls, changing estrogen is a key technique and has been proven to mitigate dementia threat (and different dangers) in girls with untimely or early menopause,” Faubion mentioned.

For years, hormone substitute remedy was extensively prescribed to deal with signs of menopause and decrease threat for coronary heart illness, osteoporosis and dementia. This all modified when the landmark Ladies’s Well being Initiative research confirmed that taking estrogen and progestin after menopause could improve girls’s threat for stroke, coronary heart illness, blood clots and breast most cancers. (Estrogen helps with menopause signs like sizzling flashes and vaginal dryness, and progestin is added to guard in opposition to uterine most cancers in girls who nonetheless have a uterus.)

As we speak, hormone substitute remedy could also be prescribed within the lowest dose for the shortest period of time to maximise advantages and decrease potential dangers.

Extra data

The Alzheimer’s Affiliation presents recommendations on stopping dementia.

 

SOURCES: Wenting Hao, MD, PhD candidate, Shandong College, Jinan, China.; Stephanie Faubion, MD, MBA, director, Heart for Ladies’s Well being, Mayo Clinic, Rochester, Minn., and Jacksonville, Fla., and medical director, North American Menopause Society; March 1, 2022, presentation, American Coronary heart Affiliation assembly, Chicago

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